Beilstein J. Org. Chem.2017,13, 779–792, doi:10.3762/bjoc.13.77
ionization like matrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI). Liquid chromatography (LC) separation with evaporativelightscatteringdetection (ELSD) and NMR analysis were employed in order to elucidate the structural profiles of the obtained mixtures. The results
clearly demonstrate that the cyclodextrins were tethered with more than one short oligolactate chain per CD molecule, predominantly at the methylene group, through ring opening of L-LA initiated by primary OH groups.
Keywords: cyclodextrin; ESI; evaporativelightscatteringdetection; liquid
we performed the reversed-phase liquid chromatography (LC) separation of the crude reaction mixture with evaporativelightscatteringdetection (ELSD) for all CD-LA products. The chromatogram depicted in Figure 1a contains two distinct groups of chromatographic peaks of β-CD-LA reaction mixture. The
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Graphical Abstract
Scheme 1:
Ring opening of L-LA in the presence of cyclodextrins.